Prerearranged T Cell Receptor Genes Development in Mice with Endogenous Early TCR Expression and Aberrant T Cell
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Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cells at a detectable but greatly reduced rate, but gamma/delta T cells are completely absent. The special role of IL-7R signaling in gamma/delta T cell development has remained unclear. IL-7Ralpha(-/-) mice exhibit a paucity of gamma gene rearrangements. This striking observation can be explained by a defect in T cell recept...
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تاریخ انتشار 2007